Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
Pharmacology & Pharmacy, 2015
Ruth Gallily1, Zhannah Yekhtin1, Lumír Ondřej Hanuš2
1The Lautenberg Center for General and Tumor Immunology, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel; 2Department of Medicinal and Natural Products, Institute for Drug Research, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel
TCannabidiol, one of the major components in the cannabis plant, has been shown to be a powerful anti-inflammatory and anti-anxiety drug that does not cause a psychoactive effect. However, it has been previously found that a dose of pure CBD has a bell-shaped response, with healing observed only in a very limited dose range, with no further positive effect achieved in lower or higher doses, which limits its clinical use. The aim of this laboratory study conducted on mice in collaboration with the Hebrew University was to examine the effect of full-plant cannabis extract on inflammation and pain, in comparison with isolated CBD and commercial anti-inflammatory and anti-nociceptive drugs. This study found that the Avidekel strain extract is a CBD source that eliminates the bell-shaped dose response.
STUDY POPULATION: lab mice.
STRAIN: Avidekel Extract
- The full-plant extract of Avidekel, which is high in CBD and low in THC, provided a correlative anti-inflammatory dose-response (i.e. as the dose was increased, the inflammation decreased in correlation), superior to the bell-shaped dose-response of isolated CBD, which exhibited less consistent anti-inflammatory properties at lower and higher doses.
- The full-plant extract of Avidekel, provided a correlative anti-pain dose-response, superior to the bell-shaped dose-response of isolated CBD, which exhibited less consistent anti-pain properties at lower and higher doses.
- Avidekel extract exhibited superior anti-inflammatory effectiveness compared to tramadol (an opioid analgesic) and aspirin (a non-steroid anti-inflammatory)