Medical cannabis for inflammatory bowel disease: real-life experience of mode of consumption and assessment of side-effects.
Eur J Gastroenterol Hepatol 2019
Timna Naftali 1 2, Lihi Bar-Lev Schleider 3, Fabiana Sklerovsky Benjaminov 1 2, Ido Lish 1 2, Fred M Konikoff 1 2, Yehuda Ringel 1 2
1Meir Medical Center Institute of Gastroenterology and Hepatology, Kfar Saba; 2Sackler School of Medicine, Tel Aviv University, Tel Aviv; 3Soroka University Medical Centre and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
An extensive observational, real-life study with 127 IBD patients who were followed at Meir Medical Center from 2011 through 2016. Most patients reported significant improvement in their symptoms and the use of other medications after 1 year of cannabis consumption was significantly reduced.
STUDY POPULATION: 127 IBD patients who received a license for use of medical cannabis
STRAIN: Half of the patients in the study received the company’s products regularly
The average dose used was 31 ± 15 g/month. The average Harvey-Bradshaw index improved from 14 ± 6.7 to 7 ± 4.7 (P < 0.001) during a median follow-up of 44 months (interquartile range, 24-56 months). There was a slight, but statistically significant, average weight gain of 2 kg within 1 year of cannabis use. The need for other medications was significantly reduced. Employment among patients increased from 65 to 74% (P < 0.05). We conclude that the majority of inflammatory bowel disease patients using cannabis are satisfied with a dose of 30 g/month. We did not observe negative effects of cannabis use on the patients’ social or occupational status.